ackground : To evaluate left ventricular diastolic function in the patients with dilated
cardiomyopathy, pulsed doppler echocardiography was used to study mitral flow velocity in 14
patients with dilated cardiomyopathy and mitral regurgitation (DCMR (+)), 18 patients with
dilated cardiomyopathy but no mitral regurgitation (DCMR (-)) and 65 normal subjects
in Heart Center Dong-A University Hospotal, between May 1990 and september 1992.
Methods : Left ventricular end diastolic dimension (LVEDD), ejection fraction (E.F.) and
left atrial dimension (LAD) were calculated from M-mode echocardiography, and A2-D
(isovolumic relaxation time), DF (the duration of early diastolic flow) E-F slope (the rate of
deceleration of early diastolic flow), E height (the maximal early diastolic blood flow velocity),
A height (the maximal late diastolic blood flow velocity) and A/E ratio were measured
from Doppler mitral flow velocity recordings.
Results :
1) LVEDD, 68±5 mm and E.F., 21±2% in DCMR (+), and LVEDD, 65±4 mm E.F.,23±
2% in DCMR (-) were significantly different from 46±4 mm and 61±6% in the normal
healthy groups. LAD, 48±6 mm in DCMR (+) and 44±5 mm in DCMR (-) were signifantly
increased being compared with LAD 32±5 mm in the normal group.
2) A2-D, 90.4±8.6 ms in DCMR (+) and 91.3±9.4 ms in DCMR (-) were significantly
longer than 70.2±11.5 ms in the normal healthy groups.
EF slope, 342.3±115.5 cm/secE2 in DCMR (+) were significantly decrease from 411.5±
125.4 cm/secE2 in DCMR (-) and 391.9±159.6 cm/secE2 in the normal control groups.
DF, 289.4±32.5 ms in DCMR (+) and 297.4±45.3 cm/secE2 in DCMR (-)
were significantly longer than 235.9±56.5 ms in the normal groups.
E height, 38.6±7.8 cm/sec in DCMR (-) was significantly decreased from 51.1±9.2 cm/sec
in the normal group and 60.4±10.2 cm/sec in DCMR (+).
A height, 48.7±8.6 cm/sec in the normal group was not significantly different from 39.7±
11.5 cm/sec and 45.4±6.4 cm/sec in DCMR (-).
A/E ratio, 1.4±0.5 in DCMR (-) was significantly increased from 1.0±0.4 in the normal
group and 0.7±0.4 in DCMR (+).
Conclusions : We confirmed that the DF (the duration of the early diastolic flow) in DC
was prolonged than in the normal group and E hEight (the maximal early diastolic blood flow
velocity) in DCMR (-) was decreased and EF slope (the rate of deceleration of early diaStolic
flow) in DCMR (-) was increased than in DCMR (+).
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